2-Aminobenzoate (anaerobic)

2-Aminobenzoate is an intermediate derived from tryptophan and other indole ring-containing compounds. The catabolism of 2-aminobenzoate has largely been studied with aerobic bacteria. Its aerobic degradation is documented elsewhere in the EAWAG-BBD. More recently, anaerobic catabolism of 2-Aminobenzoate has been studied and proceeds with initial esterification of the carboxyl group to coenzyme A ([http://www.ncbi.nlm.nih.gov/pubmed/1885526|Altenschmidt et al., 1991]). The subsequent proposed reduction of 2-aminobenzoyl-CoA to benzoyl-CoA is reminiscent of reductive deamination reported for the catabolism of nitroaromatic compounds, such as trinitrotoluene (TNT), following reduction of the nitro groups to form an aniline derivative ([http://www.ncbi.nlm.nih.gov/pubmed/1592816|Lochmeyer et al., 1992]).