Description:
Minnesota, BioC/MicE 5309. 1,2,3-Tribromopropane (TBP) is toxic organic compounds that has been released into environment via agricultural usage or the improper disposal of industrial waste ([http://www.ncbi.nlm.nih.gov/pubmed/10508091|Bosma et al., 1999]). 1,2,3-Tribromopropane is potent in causing organ damage (kidney and testis) in rats. Extensive necrosis is evident at 85 mumol/kg in kidney and at 170 mumol/kg in testis ([http://www.ncbi.nlm.nih.gov/pubmed/1793801|Lag et al., 1994]). Also 1,2,3-tribromopropane causes DNA damages. It has been shown that 1,2,3-tribromopropane is mutagenic in strains TA1535 and TA100 of Salmonella typhurinum ([http://www.ncbi.nlm.nih.gov/pubmed/1793801|Lag et al., 1991]). Also 1,2,3-tribromopropane induces dominant lethal mutation in the early spermatide stage of SD male rats ([http://www.ncbi.nlm.nih.gov/pubmed/7110159|Saito-Suzuki et al., 1982]). The recombinant strain Agrobacterium radiobacter strain AD1(pTB3) has the ability to utilize 1,2,3-tribromopropane as a sole carbon source. The initial step in the degradation of 1,2,3-tribromopropane is dehalohenation to 2,3-dibromo-1-propanol ([http://www.ncbi.nlm.nih.gov/pubmed/10508091|Bosma et al., 1999]).